Central Nervous System Intraoperative Cytopathology, Second Edition

Marilin Rosa, MD, The ASC Bulletin Editorial Board
Department of Anatomic Pathology
Moffitt Cancer Center

This new edition of “Central Nervous System Intraoperative Cytopathology” published in 2018, has been extensively revised and updated. The goal of the book, as part of the Essentials in Cytopathology book series, is to deliver a straightforward and easy to use guide containing the fundamentals of each subject. The book describes the cytopathology of common central nervous system (CNS) lesions and also incorporates new entities and histologic variants based on the 2016 WHO of CNS Tumors. The book also includes newly introduced biomarkers as well as updated clinical-radiological features that the pathologist should know. Although the topic complexity makes the authors’ task very challenging, they managed to nicely present the subject in a complete but concise way.

The book is composed of a total of 23 chapters, of which 3 are new, 2 appendices and many new full-color images. It is divided in 4 parts. Part I is the introduction in which the authors review preparation techniques, clinical and radiological approach to CNS intraoperative diagnosis, handling and processing, algorithmic evaluation of specimens, and a last chapter about the normal brain and gliosis. Part II discusses cytologic features and differential diagnosis of neoplastic lesions of the CNS. This part includes chapters on pediatric and adult primary neoplastic lesions as well as metastatic tumors to the brain. Part III includes cystic lesions, infections, inflammatory and reactive lesions. Part IV, includes a description of common neoplastic and non-neoplastic CNS lesions according to the affected regions of CNS (Pineal, Sellar, Spine and Epidural space). Appendix A presents a very useful list of benign and malignant tumors in which the results of the intraoperative consultation may alter the clinical approach and provides a brief mention of the treatment of choice. In only one page, Appendix B discusses pitfalls and dilemmas with CNS intraoperative consultation providing a list that summarizes the most characteristics intraoperative diagnostic pitfalls with reference to the page(s) in the text where they are discussed.

This wonderful succinct book has numerous tables with lots of information explaining intraoperative assessment of CNS lesions. Most of the photomicrographs are superb including high power views of diagnostic entities, in addition to MRIs, to correlate for better understanding and accuracy. You could find diagnostic approach and cytologic features with differential diagnosis for most of the subjects. Each segment is short and easy to understand with comprehensive information integrated with tables, radiological images, and cytology preparations.

This useful book is an excellent quick reference and I highly recommend it not only for pathologists, residents, fellows, but also for radiologists and clinicians.

​The Essentials in Cytopathology book series fulfills the need for an easy-to-use and authoritative synopsis of site specific topics in cytopathology. These guide books fit into the lab coat pocket and are ideal for portability and quick reference. Each volume is heavily illustrated with a full color art program, while the text follows a user-friendly outline format.

Central Nervous System Intraoperative Cytopathology covers the full spectrum of benign and malignant conditions of the CNS with emphasis on common disorders. The volume is heavily illustrated and contains useful algorithms that guide the reader through the differential diagnosis of common and uncommon entities encountered in the field of intraoperative neuro-cytopathology. This book will be a valuable quick reference for pathologists, cytopathologists, and fellows and trainees dealing with this exigent field.

Since the successful First Edition, the advances in radiological, clinical, morphological, and molecular aspects of CNS diseases, as well as the increasing options for different treatments modalities require updating of textbooks and revision of diagnostic algorithms.

 To reach this aim, Central Nervous System Intraoperative Cytopathology, Second Edition features the incorporation of 3 new chapters, 2 appendices, and all new full-color images in the text with updates of new diagnostic information according to 2016 WHO classification of CNS tumors.  This fully updated edition also includes expanded clinic-radiological approach, recent biomarkers, and cytological features of new WHO entities.

In summary, the text has been extensively revised and largely rewritten to offer the practicing pathologist a concise summary of the critical information needed to recognize and interpret the current exigent field of intraoperative neurocytopathology.


Central Nervous System Intraoperative Cytopathology, Second Edition
Authors: César R. Lacruz, Javier Saenz de Santamaria, and Ricardo H Bardales
Publisher: Springer
Price: $129.00 – eBook & $169.99 – Softcover
Softcover, 267 pages
ISBN: 978-3-319-98491-9 – (eBook)
ISBN: 978-3-319-98490-2 – (Softcover)