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Continuing Medical Education (CME): The American Society of Cytopathology is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.

The American Society of Cytopathology designates this enduring educational activity for a maximum of 1 AMA PRA Category 1 credit(s).TM Physicians should only claim credit commensurate with the extent of their participation in the activity.

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Continuing Medical Laboratory Education (CMLE): The ASC designates this activity for the indicated number of CMLE credit hours and also fulfills requirements of the ABMS to participate in the Maintenance of Certification program.

This program is approved for continuing education credits in the State of Florida for 1 credit and the State of California for ½ credit.

Clinical History

The patient is a 54 year old white female with a history of triple negative breast cancer. BRCA testing was negative. Routine Pap test identified the presence of atypical glandular cells (AGC). Concurrent HPV results were negative. As follow-up, her CA125 Ser QN was 16.5 units/ml. A pelvic ultrasound revealed a calcified mass on her left ovary.

Cytopathology Features

The cells of interest are in sheets and small clusters with a relatively clean background. The cells show moderate amounts of cytoplasm with peripherally located nuclei and some pseudostratification. The chromatin is dense; nucleoli are easily visualized. Psammoma bodies can be seen in the center of some of the cell groups.

John S. Kennedy, CT(ASCP), Marion University
Barbara McGahey Frain, MS, SCT(ASCP)
, Indiana University School of Medicine
Indianapolis, Indiana

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